Ursolic Acid

Ursolic Acid

Lean Muscle Optimizer

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Fighting Fat While Sparing Precious Muscle

When it comes to getting in shape, do you ever find yourself in a “catch 22”? Coined in the early 1960s, this expression refers to a no-win situation – one where solving one part of a problem only creates another. Picture this as an example: You clean out the junk in your diet, you begin hitting the gym, and you lose 15 pounds. Great! Mission accomplished, right? Maybe not. In your effort to lose unwanted weight, you’ve also lost a precious commodity – muscle. Your waistline may be smaller, but your body is soft, lacking definition. You’ve solved one part of the problem (the number on your scale), only to encounter another (loss of muscle tone). This is the reality for many – having to choose between fat loss and muscle growth. If only there was a way to achieve both …


Trust the Old Adage

As it turns out, an apple a day does more than keep the doctor away. A naturally occurring ingredient found in apple peels (ursolic acid) has actually been shown to support fat loss and muscle growth … and not just one or the other. People who are especially concerned about sparing – and ultimately building – muscle can be confident knowing that Labrada’s new Ursolic Acid Lean Muscle Optimizer has their goals for a lean, defined body in mind. That’s because ursolic acid has been shown to affect molecular pathways that could actually prevent muscle loss and weakness. In studies involving both humans and mice, ursolic acid helped counteract the catabolic effects of fasting/dieting. Meanwhile, in studies with just mice, this natural ingredient was found to protect against muscle atrophy (or decrease in muscle mass). In fact, when ursolic acid was added to the food of normal, non-fasted mice, their muscles grew.

For more on these and other ursolic acid studies Click Here

While ursolic acid as a dietary supplement has only recently come into the spotlight, early findings are extremely promising and human clinical trials continue. Because medicinal plants containing ursolic acid have been used in folk medicine for centuries, you can be confident this ingredient is natural, safe, and effective.


Fat Loss Anyone?

In the previously mentioned study where mice experienced muscle growth when given ursolic acid, it was also found that the mice became leaner and had lower blood levels of glucose, cholesterol, and triglycerides. This, again, is that coveted combination that many of us strive for – muscle growth and fat loss rolled into one. Supplementing with Labrada’s Ursolic Acid could make all the difference. As further shown in studies, mice that were fed ursolic acid and a high-fat diet had significantly decreased body weights, abdominal (visceral) adiposity, and levels of blood glucose and plasma lipids compared to mice on the same diet but without the ursolic acid supplement. Diet and activity levels were the same for both groups; the only “edge” was the ursolic acid. The question then remains: What could Ursolic Acid do for you?


It All Comes Back to Better Health

Labrada’s Ursolic Acid hasn’t just been designed to help you look better. It even supports cardiovascular health, making it a beneficial supplement for dieters and athletes of all ages. Because Ursolic Acid can help reduce bodyfat and blood sugar levels, it provides nutritional support that may be beneficial for both obesity and diabetes. It also plays a role in bone and joint health.


WANT TO DIG DEEPER INTO THE SCIENCE?

While studies continue on ursolic acid and its role in fat loss, muscle sparing, and the prevention of various health conditions, you can view some of the current research by Monica Mollica BSc , MSc. below.

   

Digging Deeper Into The Science

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Ursolic acid is a newly discovered substance, which is a component of apple peels. Ursolic acid has generated a lot of scientific interest lately, because it has been found to affect molecular pathways that could prevent muscle loss and weakness, promote fat loss, and have a beneficial effect on multiple chronic diseases.


What is it?

Ursolic acid, also known as urson, prunol, micromerol, and malol, is a pentacyclic triterpenoid compound which naturally occurs in a large number of vegetarian foods, medicinal herbs, and other plants, including apples and rosemary 1,2.


Anti-catabolic - Preservation of Muscle Mass

The anti-catabolic effect of ursolic acid was recently discovered in a study that looked at what happens to gene activity in muscles during catabolic situations like fasting 3. It was found that fasting in both people and mice changes gene expression in many genes. These gene expression changes were then compared to those seen in muscle fibers that had been exposed to a wide array of bioactive molecules. Of all the tested bioactive molecules, ursolic acid turned out to be a unique substance that induced a gene expression pattern that counteracted the catabolic effects of fasting.

Next, ursolic acid was given to fasted mice, and found to protect against muscle atrophy. When ursolic acid was added to the food of normal (non-fasted) mice for five weeks, their muscles grew. These effects were mediated by enhanced insulin signaling in muscle and counteracting of the gene expression pattern causing muscle atrophy.


Fat loss

In the same study 3, it was further shown that mice given ursolic acid also became leaner and had lower blood levels of glucose, cholesterol and triglycerides.

Another study specifically evaluated ursolic acid for its effects on blood glucose, lipids, and abdominal fat deposition in mice fed a high-fat diet. Mice supplemented with ursolic acid and fed a high-fat diet had significantly decreased body weights, abdominal (visceral) adiposity, and levels of blood glucose and plasma lipids compared to mice on the same diet but without the ursolic acid supplement. Also, a significant increase was observed in levels of leptin with a decrease in ghrelin 4.

Ghrelin is a hormone secreted in the stomach. It has an orexigenic (appetite increasing) effect through its action on the hypothalamic appetite-regulating pathways 5-8. It also increases adipose tissue accumulation and has a diabetogenic effect on the liver and pancreas 6.

Leptin, a hormone secreted from fat cells, has wide ranging effects in the body 9. Among all, it plays a key role in regulating energy intake and energy expenditure 9-12

Thus, the increase in leptin and decrease in ghrelin levels most likely contributed to these ursolic acid induced anti-obesity effects. Ursolic acid also has been shown to increase liberation of fatty acids from body fat stores 13,14, and inhibit fat absorption by reducing the activity of pancreatic lipase (an enzyme that is necessary for fat absorption)14. Thus, ursolic acid can help to fight off excess body fat via several complementary mechanisms.


The ability of ursolic acid to help maintain healthy blood sugar levels was further demonstrated in another study, which also found that ursolic acid stimulates liver glycogen synthesis 15. This study concluded that ursolic acid may be useful for people interested in their blood sugar levels and lipid profile, as well as by promoting liver glycogen deposition.


The walls of large arteries, when activated, recruit circulating monocytes (a type of white blood cell)16. This in turn contributes to chronic inflammation and the development and progression of atherosclerosis 16. A common condition that affects monocytes in a negative way is high blood sugar (hyperglycemia) 17, which can be caused by a high carbohydrate diet and physical inactivity. High blood sugar levels cause a low grade inflammatory state, and monocytes are important in orchestrating these effects 17. In light of this, it is interesting that ursolic acid is a potent inhibitor of monocyte dysfunction and the development of an inflammatory state. 18.

Ursolic acid also beneficially affects endothelial cells and thereby promotes cardiovascular health via other mechanisms. One of those is via an up-regulation of eNOS expression in endothelial cells and increase in bioactive vascular nitric oxide, and parallel downregulation of eNOS-dependent production of free radicals in human endothelial cells 19.

eNOS stands for endothelial nitric oxide synthase, and is the enzyme in blood vessels that produces nitric oxide. In the body, nitric oxide is an important cellular signaling molecule. Nitric oxide has gained status as one of the most important signaling molecules in the cardiovascular system, and is regarded to be a ubiquitous mediator of cardio protection 20. The origin of many cardiovascular diseases is associated with reduced nitric oxide production and availability and/or increased endothelial eNOS-dependent free radical formation 20-22. Therefore, maintaining adequate nitric oxide levels and activities in the heart and blood vessels is a promising therapeutic intervention with a high potential for effective prevention and/or treatment of cardiovascular diseases. The fact that several medicines (for ex. nitroglycerine) are active by being precursors to nitric oxide, and that medical drug research is developing medicines that target eNOS to increase its activity 21,23, proves that this mechanism is very important for cardiovascular health. Thus, ursolic acid holds great potential in being a natural dietary compound that increases eNOS actvity and nitric oxide levels.


Bone and joint health

In the field of bone health there has been growing interest in anabolic agents that enhance bone mass and improve bone architecture. It has been demonstrated that ursolic acid has anabolic effects on the skeleton by stimulating osteoblast differentiation, bone mineralization and enhance new bone formation 24.


Safety

Ursolic acid is a natural dietary substance that only recently has started to generate scientific interest. While most of the studies on ursolic acid have been made in mice and cell cultures, medicinal plants containing ursolic acid have been used in folk medicine for centuries 1. It has been established that ursolic acid is non-toxic 1, so we can count on seeing products being developed with ursolic acid as the active ingredient for different health related condition in the near future.


Bottom line

The presence of ursolic acid in apple peels and many edible plants contributes to their overall health benefits. Ursolic acid not only counteracts muscle breakdown during catabolic conditions like fasting and dieting, but also can help to reduce body fat. These effects are beneficial for the prevention and/or reduction of the severity of some illnesses. It is interesting that ursolic acid exerts its potential anti-obesity effects via both hypothalamic and metabolic targets.

In addition, ursolic acid has potent effects that beneficially could influence cardiovascular health outcomes. Ursolic acid is generating a lot of scientific interest as being a novel and bioactive molecule for drug discovery 26-31. With all the recent studies on ursolic acids, the old cliche an apple a day keeps the doctor could more specifically be restated as "an apple a day helps keep muscle wasting and body flab away".

What's in Ursolic Acid?

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Ursolic Acid
Lean Muscle Optimizer*


Supplement Facts

Serving Size: 4 Capsule
Serving Per Container: 30
Amount Per Saving %DV**

Ursolic Acid150mg+

(from rosemary Leaf Extract)

** Percent Daily Values are based on a 2,000 calorie diet.

+ Daily Value (DV) not established.

Other Ingredients:Maltodextrin, Gelatin, Silica, Magnesiun Stearate, , Titanium Dioxide,Sodium copper Chlorophyllin

Discover more about our wellness range

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  • Natural Fat Loss
    4 out of 54 out of 54 out of 54 out of 54 out of 5

    Reviewer: DeShawn T. (Atlanta , GA)

    I have increased my cardio 20 minutes 4 days a week. Take this product 3 times a day and BAM ..... it worked. I have not only lost weight, I feel better, skin seems tighter, muscle is stronger. I realize that my hard work had a lot to do with this. But I have tried working this hard before and haven't experienced these kinds of results. Good product!

  • Safe product
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: Gary F (Chandler, AZ)

    I will be honest I don't know much about supplements but from what I have learned and understand I am very comfortable with this product. Being derived from an all natural product makes me feel very comfortable with the product. I ordered 3 bottles, I am half way done one already. I feel like I am seeing results already. Very happy.

  • Longer workouts
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: Kelly Flores (Rancho Cucamonga, CA)

    I use to run for 40 minutes and feel very tired at the end. Been taking this for 2 months now. I just came in for my run and looked at my watch. I ran for 55 min and feel I could of kept going. It hit me... this product really works.

  • Great value
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: Sarah Tazner (Chattanooga, TN)

    This product has really helped me stay on track reminding me everyday of my goals when I take it. One of the best prices I could find on the market. With 3rd party testing I trust the ingredients and the brand. Great product

  • Dense Muscle
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: Jeremia H. (Lubbock, TX)

    Have had 3 containers of this stuff. Muscles feel harder and denser. I have my little brother on it now too. He is seeing similar results. I am trying to get my whole family to take it. Labrada makes good products. Recommended!

  • Great to cut fat
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: Andrew C. (Charlotte, NC)

    Personally I never liked cardio, was always afraid of losing muscle at the same time I really wanted to shed excess fat. So far I have been taking this product for 3 months lost 5 pounds and I think its all fat. I love this stuff!

  • Very pleased
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: Beth Patterson (San Antonio , TX)

    Ursolic Acid really works. It supports fat loss, Supports lean muscle and supports cardiovascular health. Very pleased, highly recommended. No stimulants which is great.

  • URSOLIC ACID ROCKS
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: Mark Rogers (Houston, TX)

    Best all-around fat loss supplement I have ever tried. It doesn’t upset my stomach, easy to take dose. Love It!!!!

  • Great New Supplement!
    4 out of 54 out of 54 out of 54 out of 54 out of 5

    Reviewer: Don Forsyth (Spring, TX)

    Being a hard gainer, its critical for me to keep the muscle I build; that’s were a good anti-catabolic supplement can make a big difference for me and Ursolic Acid does the trick. I take Ursolic Acid with Green Coffee Bean and Raspberry Ketones, this stack is helping me get leaner.

  • Surprised!
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: JJ (Spring, TX)

    I really LOVE this product! It is keeping me full, especially since I take it 3x's a day-I find that I drink more water as well.

  • ursolic acid
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: stan knapton (wichita, KS)

    Great supplement!! Within the first month of using this product I have had great gains in losing body fat and getting leaner and more vascular. I have used Labrada Nutrition since it got started and as with all the products I know the potency and product development are the best quality, I know whats on the bottle is in the bottle.

  • Best New Supplement On The Market!
    4 out of 54 out of 54 out of 54 out of 54 out of 5

    Reviewer: James Cipriani (Danbury, CT)

    I have recently gotten away from "performance" based training and back to my bodybuilding roots. With that, I have zoned my nutrition in to bring out more detail in my muscle. I have added a supplementation plan, as well, to help augment my training and diet. Ursolic Acid my new found favorite. I predict you will be hearing a lot more about this compound in the near future. I think Ursolic Acid is the most significant muscle-growth enhancing compound to come along in decades. It certainly has serious science to back it up. Since starting the usage of Ursolic Acid, I have noticed that it has triggered lean muscle growth, increased strength and accelerated fat loss. I love it with my new stack consisting of Green Tea Extract, and Raspberry Ketones. And nobody beats Labrada quality. http://www.jimcipriani.com

  • Ursolic Acid A++ :)
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: Megan H (Spring Branch, TX)

    I started taking Ursolic Acid about a month ago and I have stated to notice a significant difference in my stomach area. My skin is tightening up and looking much leaner :) Love it! Awesome Product!

  • Better than I expected.
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: jim casagrand (bayville, NJ)

    I bought the ursolic acid based on reading a clinical study in which it was used. I found that it does, in fact, help with blood sugar control (I am a type-1 diabetic who also has hypothyorid) and has allowed me to add to my muscle mass while helping to preserve what I already have - very difficult when you have these 2 diseases. In addition, I've noticed marginal strength gains. I take 6 caps a day with meals, and it's the only change in my regimen I made since I noticed the results. Most promising supplement I've come across in a long time. If it helps me this much, I can only imagine it will help healthy individuals that much more. Full disclosure - I am a dieatary supplement formulator and have worked in the industry for over 17 years. I currenly work for a large contract manufacturer in regulatory and compliance, but we make nothing for Labrada or any other sports suppement brand.

  • Holy Cow! Awesome!
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: Tiffani Feathers (The Woodlands, TX)

    I had to take some time off from my gym schedule after having surgery and this supplement helped me not only maintain my muscle, but actually lose body fat! I was able to jump back into my spandex for the gym without a second thought. I was actually even more excited to get back to training, knowing that my progress wasn't held back by my time off. Love this!

  • Simply Brilliant
    5 out of 55 out of 55 out of 55 out of 55 out of 5

    Reviewer: Brock Balouch (Seguin, Texas )

    Perfect natural supplement for enhancing performance, strength, increasing energy, building muscle, and fast fat loss.

 

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