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It has been substantiated that testosterone is the most powerful muscle-building hormone produced naturally within the body. Unfortunately, as we age, testosterone levels naturally decline and this can hinder our ability to lose fat and build muscle.

Testosterone is an anabolic, androgenic steroid hormone produced by the testes that promotes the development of male sex characteristics and regulates male reproductive function. It has been substantiated as the most powerful muscle-building hormone produced naturally within the body (it also is strongly implicated with fat loss). Note that this isn’t saying that testosterone is outright the strongest muscle-building hormone, as there are hormones that we don’t naturally produce in the body that are much more potent in that regard.

As we age, testosterone levels naturally decrease (especially as we get into our 30s and 40s), so support of natural testosterone production is imperative as we become older. There are many reasons testosterone (and other androgens) are so heavily researched, and it’s quite clear that these compounds have a myriad of anabolic actions in the human body.

For example, testosterone is a strong inhibitor of amino acid oxidation and increases whole-body and skeletal muscle protein synthesis (and also appears to have anti-catabolic effects of muscle tissue ).1 Thus, increasing testosterone levels increases net muscle protein balance, resulting in increased muscle mass (especially when combined with proper diet and training).2

Like most other hormones in the body, many factors play into regulating production of testosterone; below is an abbreviated list of the most important lifestyle variables that effect its production (or lack thereof). Positive effectors:
• Adequate sleep3
• Fat loss (to a degree, since fat cells secrete aromatase)
• Vigorous exercise (especially resistance training)4
• Abstinence (for roughly one week at a time)5

Negative effectors:
• Obesity/Over-fatness
• Diabetes (specifically type-II diabetes)6
• Sedentary lifestyle/inactivity7
• Sleep loss/deprivation
• Lack of fat in the diet (since fat is needed to synthesize androgens)
• Prolonged aerobic/cardiovascular exercise8
• Excessive alcohol intake9
• Xenobiotics10

There are natural compounds that can support testosterone levels, especially those found in Labrada’s Humanogrowth™ formula. Humanogrowth™ can help naturally boost your testosterone levels so you can build more muscle and lose more fat.

Effects of Humanogrowth™ on Natural Testosterone Production
Humanogrowth is a patent-pending blend of key growth fact ors and biologically-active peptides that help boost your body’s natural production of testosterone (and other key hormones such as growth hormone). In turn, this results in a variety of beneficial effects for fitness and health enthusiasts including:
• Increased muscle growth
• Increased fat loss
• Enhanced sex drive
• Proper cortisol/stress management
• Reduced inflammation and oxidative stress
• Promoted sense of wellbeing
• Improved sleep duration and quality

But just how does Humanogrowth™ elicit these effects? Well for starters, the ingredients in Humanogrowth™ act to increase the body’s production of growth hormone (GH). GH is a peptide hormone produced in the pituitary gland that stimulates cellular growth and reproduction. When we are well-nourished (such as after a meal), GH stimulates production of insulin-like growth factor- 1 (IGF-1) once it reaches the liver which subsequently promotes growth of lean body mass.11 When we are in a fasting state, GH primarily stimulates the release of stored fatty acids for use as energy, thereby preserving muscle tissue and glycogen stores.12

Research has shown that GH acts to block amino acid oxidation and thus spares essential amino acids for incorporation into proteins rather than being used for energy.13 Curiously though, it appears that increases in muscle protein synthesis from GH are likely the result of increased IGF-1 release (recall from earlier that GH stimulates production of IGF-1 from the liver). Testosterone also increases IGF-1 production, making both it and GH highly beneficial for growth of skeletal muscle tissue.

Furthermore, it has been shown that GH also inhibits protein degradation (proteolysis), and it is likely that this effect is seen in skeletal muscle tissue also due to local expression of IGF-1.14 So as we can see, IGF-1 is certainly a potent hormone for boosting lean muscle mass. IGF-1, in brief, is a peptide hormone quite similar in molecular structure to insulin that has implications on the growth of humans.

Many factors influence the amount of IGF-1 (and GH) present in the blood at any given moment, including: genetics, circadian rhythms, age, physical activity, nutrient status, stress, disease state, ethnicity, and others. IGF-1 is a potent initiator of the AKT signaling pathway in cells, which has significant ramifications on cell growth and proliferation. 15 Therefore, as aforementioned, increased levels of IGF-1 promote skeletal muscle anabolism and protect the body from breaking down muscle tissue for energy.

Conclusion
With all the physiology mumbo-jumbo out of the way, let’s recap the take-home message from this article. Humanogrowth™ contains key ingredients that boos t GH, IGF-1 and testosterone levels, naturally. In turn , this has significant benefits on a multitude of functions in the body, particularly with regards to increasing muscle mass, promoting fat loss, boosting libido, and enhancing sleep. The key thing to remember is that Humanogrowth™ is completely natural and doesn’t shutdown your body’s natural production of hormones like prohormones and steroids do.

Also note that in recent years some supplement companies have tried to make the claim that deer antler velvet extracts are beneficial for muscle growth and fat loss as they contain IGF-1. However, these supplements are typically flawed/bunk, as the IGF-1 in these extract is rap idly cleaved (broken down) in the gastrointestinal (GI) tract before it gets into circulation (unlike the peptide matrixes found in Humanogrowth).


Resources:
1 Young, Nicholas R., et al. “Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception.” The Journal of Clinical Endocrinology & Metabolism 77.4 (1993): 1028-1032.

2 Griggs, R. C., Kingston, W., Jozefowicz, R. F., Herr, B. E. , Forbes, G., & Halliday, D. (1989). Effect of testosterone on muscle mass and muscle protein synthesi s. Journal of Applied Physiology , 66 (1), 498-503.

3 Andersen, Monica L., et al. “The association of testosterone, sleep, and sexual function in men and women.” Brain research 1416 (2011): 80-104.

4 Vingren, Jakob L., et al. “Testosterone physiology in resistance exercise and training.” Sports medicine 40.12 (2010): 1037-1053.

5 Jiang, Ming, et al. “A research on the relationship between ejaculation and serum testosterone level in men.” Journal of Zhejiang University SCIENCE A 4.2 (2003): 236-240.

6 Boyanov, M. A., Z. Boneva, and V. G. Christov. “Testost erone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency.” The Aging Male 6.1 (2003): 1-7.

7 Hulmi JJ, Ahtiainen JP, Selänne H, Volek JS, Häkkinen K, K ovanen V, Mero AA (May 2008). “Androgen receptors and testosterone in men — effects of protein ingestion, resistance exercise and fiber type”. J. Steroid Biochem. Mol. Biol. 110 (1 – 2): 130 – 7.

8 Daly, W., et al. “Relationship between stress hormones and testosterone with prolonged endurance exercise.” European journal of applied physiology 93.4 (2005): 375-380.

9 Heinz, Andreas, et al. “Hypothalamic-pituitary-gonadal axis, prolactin, and cortisol in alcoholics during withdrawal and after three weeks of abstinence: comparison with healthy control subjects.” Psychiatry research 56.1 (1995): 81-95.

10 Scarth JP (2006). “Modulation of the growth hormone-insulin-like growth factor (GH-IGF) axis by pharmaceutical, nutraceutical and environmental xenobiotics: an emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression. A review”. Xenobiotica 36 (2 – 3): 119 – 218.

11 Fryburg, David A. “Insulin-like growth factor I exerts growth hormone-and insulin-like actions on human muscle protein metabolism.” American Journal of Physiology-Endocrinology And Metabolism 30.2 (1994): E331.

12 Inoue, Yoshifumi, Edward M. Copeland, and Wiley W. Souba . “Growth hormone enhances amino acid uptake by the human small intestine.” Annals of surgery 219.6 (1994): 715.

13 Møller, Niels, and Jens Otto Lunde Jørgensen. “Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects.” Endocrine reviews 30.2 (2009): 152-177.

14 Mauras, Nelly, et al. “Insulin-Like Growth Factor I and Growth Hormone (GH) Treatment in GH-Deficient Humans: Differential Effects on Protein, Glucose, Lipid, and Calcium Metabolism 1.” The Journal of Clinical Endocrinology & Metabolism 85.4 (2000): 1686-1694.

15 Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R. , Nunez, L., Stitt, T. N., … & Glass, D. J. (2001). Mediation of IGF-1-induced skeletal myotube hypertrophy by PI (3) K/Akt/mTOR and PI (3) K/Akt/GSK3 pathways. Nature cell biology , 3 (11), 1009-1013.

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